Single-step electrical field strength screening to determine electroporation induced transmembrane transport parameters
نویسندگان
چکیده
منابع مشابه
Effect of Cell Size and Shape on Electric Field Threshold and Critical Transmembrane Voltage for Electroporation
Introduction: Electroporation is a technique for increasing the permeability of the cell membrane to otherwise non-permeate molecules due to an external electric field. This permeability enhancement is detectable if the induced transmembrane voltage becomes greater than a critical value which depends on the pulse strength threshold. In this study, the variabil...
متن کاملModel of Cell Membrane Electroporation and Transmembrane Molecular Transport
Electroporation is a technique in which, under the influence of electric field, the permeability of the cell membrane increases due to the formation of pores in the cell membrane, providing pathways for molecular transport (Abidor et al. 1979, Neumann et al. 1998, Tsong 1991, Weaver and Chizmadzhev 1989, Zimmermann 1982). As electroporation is usually evaluated by indirect indications (Gehl and...
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Using low-resistance electrical contacts, we have measured the intrinsic high-field transport properties of metallic single-wall carbon nanotubes. Individual nanotubes appear to be able to carry currents with a density exceeding 10(9) A/cm(2). As the bias voltage is increased, the conductance drops dramatically due to scattering of electrons. We show that the current-voltage characteristics can...
متن کاملEffects of electroporation on optically recorded transmembrane potential responses to high-intensity electrical shocks.
The outcome of defibrillation shocks is determined by the nonlinear transmembrane potential (DeltaVm) response induced by a strong external electrical field in cardiac cells. We investigated the contribution of electroporation to DeltaVm transients during high-intensity shocks using optical mapping. Rectangular and ramp stimuli (10-20 ms) of different polarities and intensities were applied to ...
متن کاملeffect of cell size and shape on electric field threshold and critical transmembrane voltage for electroporation
introduction: electroporation is a technique for increasing the permeability of the cell membrane to otherwise non-permeate molecules due to an external electric field. this permeability enhancement is detectable if the induced transmembrane voltage becomes greater than a critical value which depends on the pulse strength threshold. in this study, the variabil...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2016
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2016.05.022